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How ovarian reserve decreases with age

Aging is the biggest enemy for female reproductive life, which starts with first menstruation and lasts till menopause. Today women are putting bigger effort on building career not family therefore getting married later than our ancestors did. We can postpone giving birth to our children, but it is not possible to stop our biological clock and activate it when we will feel ready.

Different from males, females lose fertility more rapidly, because of the ovaries, which age more quickly than uterus, the pituitary gland, pancreas or any other tissues in female body. Aging process effects both - the number and quality of the oocytes in the ovaries. They both decrease and reach to a point beyond that no more viable offspring may be produced.

There are women who still do proceed enough hormones to get their period, but having regular menstruations, does not show you what your egg reserves in ovaries is like, they still can be low.

Every woman can go through several tests that can assess a woman’s ovarian reserve

Under the age of 35

IUI/IVF/ICSI treatments as most suitable for Young and healthy woman who are still in the best reproductive age but based on some issues that they are facing cannot get pregnant by themselves. Such women need a consultation with our reproductology specialist, carry out all necessary examinations and take tests. Based on the results of the tests and examinations, our fertility specialist can make an individual treatment plan, which he then coordinates with the patient, taking into account her personal wishes and possibilities. More detailed information can be found in Infertility Diagnostics and Treatment - Assisted Reproductive Technologies 

Between the ages of 36 and 45

IVF/ICSI+PGS testing for the embryos is recommended for the woman who are stepping out of women’s reproductive age. Aging process effects both - the number and quality of the oocytes in the ovaries. Genetic testing (PGS) helps us select only healthy embryos for the implantation and avoid failed implantation, genetic disorders in embryos and miscarriages. Here we are not talking about the quantity, but quality. Learn more.
The table below shows how the number of normal embryos in patients decreases with age.
(Data are provided by Reprogenetics, based on a study of 10,852 cycles and 58,798 blastocysts.)

Between the ages of 46 and 50

Egg donation/Tandem treatment/Egg donation treatment with PGS testing
When the body is starting to get lazy on producing eggs and the quality of them are reaching the lowest point, woman cannot make her own offspring anymore. For that reason, evolution in medicine have discovered donors as an opportunity to fool our biological clock. Woman is still capable to give birth to a child and rise a new human being, with little help from our side.

It is not an easy decision to make, but woman who decide to take this path are always forgets all the worries and fears at the moment, when the first heart beats reaches their ears and even more, when little feet or hand starts touching them from the inside, leaving the marks on the tummy. 

If woman has a very strong desire to use her own cells for fertilization and her reproductive health allows this, there is an opportunity to try a new approach: tandem treatment – combination of own + donor eggs in the donor cycle. The correlation of own and donor eggs in such treatment varies depending on the reproductive health of a woman in this period of her life.

Our clinic has a chance to select individual donor from 110 women, who are tested and approved by our clinic specialists (reproductologist, geneticist, psychiatrist-narcologist). More about our donors you can read in Egg Donation 

If pregnancy does not occur for unknown reasons, even in the donor cycle, Egg donation treatment with PGS testing is recommended (preimplantation genetic screening of embryos to choose for the embryotransfer only genetically healthy embryos that does not carry any mutations).