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Endometrium and ovaries restoration with the help of PRP-therapy

iVF Riga Clinic provides a new, advanced method of treatment – endometrium and ovaries restoration with the help of PRP-therapy (autologous platelet-rich plasma).

PRP-therapy is applied to restore menstrual cycle and folliculogenesis in menopausal and perimenopausal (in the pre-climactic period) women.
PRP-therapy (autologous platelet-rich plasma) is the treatment with own blood plasma enriched with platelets – blood cells containing many alpha-granules with a large number of growth factors. Growth factors play a key role in tissue regeneration, activate cell growth and their renewal. When high concentrated platelet-derived factors are injected into the damaged or atrophied tissues, tissues healing and regeneration processes are activated. Platelet-rich plasma growth factors are considered to stimulate follicles ovulation in the ovaries.

PRP-therapy application in gynecology

  • As an alternative therapeutic method in the cases of chronic endometritis and endometriosis. These diseases can initiate inflammation processes that can make embryo implantation difficult in both natural pregnancy and IVF cycles. Application of the PRP injections helps to eliminate inflammation processes in the uterus, as well as enhances the activity of the progesterone receptors that stimulates proper growth of the endometrium and, in turn, helps to the implantation of the embryos. After this therapy, it is possible to continue IVF treatment with better results.
  • In the cases of ovarian failure syndrome, PRP-therapy foster ovarian rejuvenation. If to inject PRP into the ovaries of menopausal and perimenopausal women, it is possible to restart menstrual cycle, which makes it possible to receive and then fertilize the eggs that produced women’s ovaries.

This innovation technique can help women of advanced maternal age or with ovarian failure syndrome. However, it should be understood that PRP-therapy is not the assisted reproduction method, it is a technique for menstrual cycle and folliculogenesis restoration in the specific cases.

Stages of PRP-therapy

PRP-therapy is carried out in several stages. First, 8-20 ml of peripheral blood is taken from the patient. Then, this blood is placed in a centrifuge and centrifuged - divided into components. Red blood cells and leukocytes are removed from the blood, leaving platelets. The platelets are then concentrated. This technique allows to obtain platelet-rich plasma, in which the platelet concentration is 3-5 times higher than in peripheral blood.


  • Chronic endometritis and endometriosis
  • Patients with poorly developed endometrium, who cannot obtain the desired level of endometrial thickness for successful embryo transfer
  • Menopausal and perimenopausal women
  • Ovarian failure syndrome
  • Recurrent failed IVF cycles

How safe is PRP-therapy?

No side effects of PRP therapy have been found. Since the patient's own blood is used for the injection, any allergic reactions are excluded and full biocompatibility is ensured.
The application of PRP-injections can work differently for different women. Therefore, it is difficult to say how many eggs can be obtained after PRP-therapy: it depends on the condition of the woman's reproductive system before the procedure, and also on the reaction to PRP-therapy. In any case, even spontaneous ovulation and the production of single eggs in menopausal and perimenopausal women, when the ovaries are already practically atrophied, is a breakthrough in reproductive technologies that could potentially give a chance for pregnancy with own eggs.
This method has been applied since 2015 and has already been tested on more than 700 women; announced at three international congresses, showed good results and condition improvement.


Contact our patient's coordinators!
Jelena Silkalna
Jelena Silkalna
Zita Gaidule (on maternity leave)
Zita Gaidule (on maternity leave)
Marina Valetko
Marina Valetko

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