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14th International Conference on Preimplantation Genetic Diagnosis (PGS and PGD)

The international conference on preimplantation genetic testing (PGS, preimplantation genetic screening, and PGD, preimplantation genetic diagnosis) took place in Chicago (USA) from 11 to 13 May 2015. This was the 14th time that the annual meeting of qualified experts in the field of reproductive genetics was held. Specialists from iVF Riga clinic (medical geneticist Liene Korņejeva and molecular geneticist Ludmila Voložonoka) also took an active part in the conference. The participants of the conference discussed the three methods of preimplantation genetic testing and gave a critical assessment of their effectiveness. The collected data served as a basis for presenting strong arguments in favour of the use of methods of preimplantation genetic screening within ART (assisted reproductive technologies). Data showed an improvement in the results of artificial fertilization in recent years when preimplantation genetic testing (PGS and PGD) was used in the cycle. This can be explained by the appearance of two new techniques, aCGH and NGS, which make it possible to test the complete set of chromosomes in contrast to the earlier method called FISH. The emergence of the aCGH and NGS methods was a real breakthrough in the preimplantation genetic testing (PGS and PGD). The new technologies have been approved as an accurate and reliable method that ensures the transfer of a healthy embryo into the uterus, thus increasing the chances of successful implantation and birth of the child. Both methods have shown good results in the cycle of in vitro fertilization. Based on the vast amount of data collected, it has been confirmed that screening of all chromosomes for aneuploidies is becoming one of the modern technologies necessary for the selection of viable embryos for transfer into the uterus and serving as a standard procedure to improve the results in a cycleof in vitro fertilization. Arguments in favour of preimplantation genetic diagnosis of all chromosomes for aneuploidies in the case of monogenic diseases (PGD) have also been set out. Since 2014, iVF Riga clinic has actively implemented comprehensive testing of all embryonal chromosomes (PGS) for aneuploidies by aCGH. In July 2015, the first baby was born thanks to the selection of a healthy and viable embryo using PGS by aCGH. Soon, iVF Riga clinic plans to conduct preimplantation genetic diagnosis (PGD) in the case of monogenic diseases. The PGD of embryos in a cycle of in vitro fertilization will enable couples who are faced with genetic abnormalities in the family to have a healthy baby. PGD makes it possible to eliminate the pathologies and select a healthy embryo for transfer into the uterus. Thanks to PGD, couples will not be faced with a choice of terminating the pregnancy in the case of a positive prenatal genetic testing.

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