Alpha-glucosidase is an enzyme that is produced in the epididymis. The level of activity of alpha-glucosidase depends on the secretory function of the epididymis. Reduced activity of alpha-glucosidase may be a sign of a complete or partial obstruction of the epididymis and ejaculatory ducts caused by inflammation or infection. An alpha-glucosidase test can therefore reveal a secretory dysfunction of the epididymis and reduced quality of the semen caused by this disorder.
The level of alpha-glucosidase in men with normozoospermia, but with reduced sperm motility (asthenozoospermia) can be an indicator of the functional failure of the epididymis, leading to changes in the membranes of germ cells and pathologies in the middle region or tail of the sperm.