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Genetic testing of missed abortion material

Genetic Laboratory of the Centre for Reproductive Genetics of iVF Riga Clinic carries out missed abortion material genetic testing basing on a complex analysis of all fetal chromosomes using NGS method (Next generation sequencing). With the help of this testing may identify unbalanced chromosomal changes in 1-22 pairs of autosomes and in the X, Y sex chromosomes and get a clear answer to the question, whether the cause of an interrupted pregnancy are fetal chromosomal abnormalities. The result can help the patients find the cause of miscarriage and to develop a strategy for successful conceiving and carrying of planned pregnancy. DNA contamination test is carried out to exclude mother DNA contamination.

What to do if you are faced with a miscarriage?

  • To collect missed abortion material (chorion villi) and brought it to the clinic (the material should be placed in a sterile container with the addition of physiological saline (0,9% NaCl solution) in such amount that completely covers the sample. It can be stored in the refrigerator for 1-3 days at a temperature of 2-8o C before the delivery).
  • To register missed abortion material at the clinic, presenting an identity document and filling in the referral card.

(The price – 300 euros. The results can be obtained in 3-4 weeks).

If missed abortion material was stored in the paraffin block in the pathological department of the hospital and sent for histological examination, it is valid for fetal chromosomal profiling if there are chorion villi found in it. (The price – 340 €).

  • If chromosomal changes are found in the chorion villi, a consultation with a doctor-geneticist is recommended to make a further plan to achieve a successful outcome. (The price – 150 euros).
  • If chromosomal changes are not found in the chorion villi, it is recommended in-depth examination with a new panel of tests  Missed abortion 1:  Molecular testing for thrombophilia (F5, F2 and MTHFR gene variants) +PAI determination  (Plasminogen activator inhibitor) for in-depth examination of predisposition to congenital thrombophilia. (The price – 250 euros.)
  • If due to various reasons were unable to collect missed abortion material or there are several missed abortions in a women’s anamnesis, it is recommended testing panel  Missed abortion 2: Molecular testing for thrombophilia + PAI determination + Mother’s karyotype (a set of chromosomes) determination. (The karyotype determination is recommended to the both parents!)

(The price – 375 euros.)

Depending on the obtained results, a consultation with a gynecologist or a geneticist is recommended to determine the etiology of interrupted pregnancy (150–175 euros).

The results can be obtained within 4 weeks from the time of registration of the sample at the clinic.

Contact our patient's coordinators!
Jelena Silkalna
Jelena Silkalna
Contact!
Zita Gaidule (on maternity leave)
Zita Gaidule (on maternity leave)
Contact!
Marina Valetko
Marina Valetko
Contact!

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